�Proteomes to unravel gonadotrophs
Although the basic developmental ancestry of pituitary body gonadotrophs is known, it has been harder to associate specific changes in gene expression with maturation due to the limited cell population. In an article on p. 546 of the September 2008 issue of Biology of Reproduction, Feng et al. take the approach of comparing the nuclear proteome of two gonadotropic cadre lines that were immortalized at different stages of development. Their results demonstrate changes in proteins that reflect regulative control of transcription and post-transcriptional processing, thus egg laying a framework to guide experimental depth psychology of the complex sequelae of events that lead to suppurate gonadotropic function in animals.
Jiajun Feng, Mark A. Lawson, and Philippa Melamed.
A Proteomic Comparison of Immature and Mature Gonadotrophs in Mice Reveals Novel Differentially Expressed Nuclear Proteins That Regulate Gonadotropin Gene Transcription and RNA Splicing.
Biol Reprod 2008; 79:546-561. Published online in BOR-Papers In Press 14 May 2008; DOI 10.1095/biolreprod.108.068106
Pollution and placenta
Urban air pollution is associated with poor and adverse maternity outcomes, including low birthweight, premature birth, and intrauterine growth subnormality. In a paper on p. 578 of the September 2008 issue of Biology of Reproduction, Veras and coworkers present evidence that the effects of urban breeze pollution on pregnancy outcomes could be related to changes in functional morphology of the placenta. The experiments employed a novel approach in which pregnant female mice were exposed before or during gestation to filtered or nonfiltered air in exposure william Chambers placed in the garden of the University of Sao Paulo School of Medicine in Brazil. The garden is situated close to a crossroads with high traffic density with about 83,900 cars, 9,900 diesel vehicles, and 6,300 motorcycles circulating casual on the main street of this intersection. Pregnant mice uncovered to urban air pollution either ahead or during gestation produced fetuses of smaller weights compared to those provided filtered zephyr. In addition, the personal effects of urban air befoulment were base to be due to adaptive changes in eutherian mammal development that ultimately come down placental part and compromise fetal emergence. This is a novel model to dissect the mechanisms of how specific pollutants influence development of the placenta and foetus. These findings are important with respectfulness to the possible transplacental transfer of pollutants from mother to fetus as well as fetal programing and developmental origins of health and disease in adults.
Mariana Matera Veras, Nilsa Regina Damaceno-Rodrigues, Elia Garcia Caldini, Antonio A.C. Maciel Ribeiro, Terry M. Mayhew, Paulo H.N. Saldiva, and Marisa Dolhnikoff.
Particulate Urban Air Pollution Affects the Functional Morphology of Mouse Placenta.
Biol Reprod 2008; 79:578-584. Published on-line in BOR-Papers In Press 28 May 2008; DOI 10.1095/biolreprod.108.069591
Source: Judith Jansen
Society for the Study of Reproduction
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Saturday 23 August 2008
Wednesday 13 August 2008
Arctic Monkeys team up with former member
Ibiza Rocks played host to a Sheffield reunion last night (August 12) when Arctic Monkeys' Matt Helders teamed up with ex-bandmate Andy Nicolson to DJ.
Steel city preacher man Jon McLure also performed live with his band Reverend And The Makers outdoors on a microscope stage by the poolside at the island's pioneering indie/dance night.
Helders and Nicolson played two hip-hop heavy sets over the course of the night - the number one one external by the pool which started with House Of Pain's 'Jump Around', the second was indoors at the club's official aftershow and included Dead Prez's 'Hip-Hop', MIA's 'Galang' and 'Fix Up Look Sharp' by Dizzee Rascal.
Hundreds of holidaying British punters flocked to the Ibiza Rocks Hotel to watch The Rev, who was also supported by wide-any indie popsters The Click Click and Club NME DJs.
Ibiza Rocks continues next Tuesday (August 19) with The Streets playing live.
More info
Steel city preacher man Jon McLure also performed live with his band Reverend And The Makers outdoors on a microscope stage by the poolside at the island's pioneering indie/dance night.
Helders and Nicolson played two hip-hop heavy sets over the course of the night - the number one one external by the pool which started with House Of Pain's 'Jump Around', the second was indoors at the club's official aftershow and included Dead Prez's 'Hip-Hop', MIA's 'Galang' and 'Fix Up Look Sharp' by Dizzee Rascal.
Hundreds of holidaying British punters flocked to the Ibiza Rocks Hotel to watch The Rev, who was also supported by wide-any indie popsters The Click Click and Club NME DJs.
Ibiza Rocks continues next Tuesday (August 19) with The Streets playing live.
More info
Wednesday 6 August 2008
Disease Prevention Programs Could Generate Substantial Savings In Health Care Costs, Report Finds
�
Investing $10 per person per year in community disease bar programs could save the U.S. $2.8 1000000000 in wellness costs all over two years and $16.5 zillion over five years, according to a study released on Thursday by Trust for America's Health, the Miami Herald reports. For the composition, researchers victimised a computing device model developed by the Urban Institute and reviewed evidence-based studies from the New York Academy of Medicine. The studies analyzed community-based bar programs that promote physical activity, skillful nutrition and smoking cessation (Dorschner, Miami Herald, 7/18).
The report provides state-by-state findings that were reached by calculative potential decreases in chronic diseases based on a $10 investment per soul. Researchers
Investing $10 per person per year in community disease bar programs could save the U.S. $2.8 1000000000 in wellness costs all over two years and $16.5 zillion over five years, according to a study released on Thursday by Trust for America's Health, the Miami Herald reports. For the composition, researchers victimised a computing device model developed by the Urban Institute and reviewed evidence-based studies from the New York Academy of Medicine. The studies analyzed community-based bar programs that promote physical activity, skillful nutrition and smoking cessation (Dorschner, Miami Herald, 7/18).
The report provides state-by-state findings that were reached by calculative potential decreases in chronic diseases based on a $10 investment per soul. Researchers
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